Monday, June 28, 2010

Dr. Andrew Wakefield's Findings Replicated in MMR link to Autism

This is not new news, but I just came across it.

January 28, 2010

Wakefield's Science Proven Valid Again In New Study That Replicates Findings
Read the full study, Clinical presentation and Histologic Findings at Ileocolonoscopy in Children with Autistic spectrum Disorder and Chronic Gastrointestinal symptoms at Autism Insights . View a .pdf HERE.
Arthur Krigsman 1, Marvin Boris 2, Alan Goldblatt 3 and Carol Stott 4

Abstract Background: Children with developmental disorders experience chronic gastrointestinal symptoms. Aims:To examine the nature of these gastrointestinal symptoms and histologic findings in children with autism spectrum/developmental disorders and ileocolonic disease.

Methods: Chart review. 143 autism spectrum/developmental disorder patients, with chronic gastrointestinal symptoms, undergoing diagnostic ileocolonoscopy.

Results: Diarrhea was present in 78%, abdominal pain in 59% and constipation in 36%. Ileal and/or colonic lymphonodular hyperplasia (LNH), defined as the presence of an increased number of enlarged lymphoid follicles, often with hyperactive germinal centers, was present in 73.2%. Terminal ileum LNH presented visually in 67% and histologically in 73%. Colonic LNH was multifocal and presented histologically in 32%. Ileal and/or colonic inflammation presented in 74%, consisting primarily of active or chronic colitis (69%). Ileal inflammation presented in 35%.

Presence of LNH significantly predicted mucosal inflammation. Patients with ileal and/or colonic LNH had lower mean/median age than those without; patients with ileal and/or colonic inflammation had lower mean/median age than those without. There was a significant association between ileo and/or colonic inflammation or LNH, and onset of developmental disorder; plateaued or regressive onset conferred greater risk than early onset.

Conclusions: Patients with autism or related disorders exhibiting chronic gastrointestinal symptoms demonstrate ileal or colonic inflammation upon light microscopic examination of biopsy tissue. Further work is needed to determine whether resolution of histopathology with appropriate therapy is accompanied by GI symptomatic and cognitive/behavioral improvement.

Keywords:ASD ileitis, colitis, lymphonodular hyperplasia
1 Assistant professor of pediatrics, New York University school of Medicine Director of Gastroenterology services, Thoughtful House Center for Children, 3001 Bee Caves Rd, Austin, Texas, 78746, UsA. 2 Associate Clinical professor of pediatrics, New York University school of Medicine, 550 1st Ave., New York, NY 10016, UsA. 3 Adjunct professor Touro College, 27-33 West 23rd st, New York, NY 10010, UsA. 4Thoughtful House Center for Children, 3001 Bee Caves Rd, Austin, Texas, 78746, UsA. Autism Insights 2010:2 1–11 This article is available from © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted commercial use is permitted provided the original work is properly cited.

1 comment:

Tracey said...

Hi Sunny, have you considered homeopathy for Kyan? There are several mothers in my local support group that are using houston center for homeopathy. I believe they do phone consults. I also am considering taking a course to learn how to use remedies with my kids and family. This is a post from my local group:
> > > Clearing the vaccines has made a night and day difference. We have
> > > very few issues w/ gut and are on no anti-fungals, antibiotics or
> > > special diets (healthy, organic) to keep the gut bugs away.
> > >

> > > I would say clearing the MMR over and over for the past year and
> > > seeing measles and rubella coming out of the skin were evidence
> > > enough to me that the mmr had damaged my son's gut. I know of a few
> > > who do well w/ meds but my son was starting to develp oxalate issues
> > > (painful urination) as a side effect and the yeast always came
> > > back. I just wanted to share a success story w/ the gut to give you
> > > hope that the body can heal itself if given the opportunity. Our
> > > practioners are at:
> > > and also for more info on the method:
> > >
> > > I think there are others who have had gut healing as well in this
> > > group when nothing else worked. I am told by other parents that the
> > > popular Dan's dr, like Usman, Megson are referring their "severe gut
> > > kids' to Hch. I also recently heard that the famous pediatric gatro
> > > doc, Dr. Buie was amazed at some pre and post testing of one of his
> > > patients who refused medication in favor of the hch method. He had
> > > never seen results like it and encouraged the mother to keep doing
> > > it and her daughter has since lost her diagnosis.

In addition to toxicity, it seems that some children have underlying viruses, strep, lyme, etc. that can be cleared with homeopathy.